Doctors warn vs online trend of mixing diabetes and weight loss drugs

The severe health risks of mixing different weight loss medications without a doctor’s supervision.

Medical professionals are warning against the “GLP-1 stacking” online trend, where various diabetes and weight-loss drugs are combined without expert supervision.

Endocrinologist Dr. John Anthony Dueñas told radar that taking these drugs—whether taken alone or in combination with others—should always be used under medical supervision.

“Combining different GLP-1s is dangerous because it can increase risks of hypoglycemia and it can enhance its gastrointestinal side effects,” Dueñas said.

GLP-1 agonists, sometimes referred to as peptides, are prescription-only drugs used to treat diabetes and obesity. They work by targeting hormones that regulate appetite, blood sugar, and digestion.

Online discussions have recently emerged around self-medication using tirzepatide and semaglutide. One Threads user even claimed to be “stacking” eight different weight loss drugs.

Wellness influencers have also promoted GLP-1 drugs as “weight loss supplements,” despite known health risks like digestive complications, pancreatitis, and gallstone attacks.

Independent online sellers—largely unregulated by the Department of Trade and Industry and the Philippine Food and Drug Administration—have also surfaced, offering access outside accredited pharmacies and clinics.

The U.S. FDA has warned that combining GLP-1 agonists may lead to overdose, worsening side effects. Improper injection and unsupervised use may also result in complications.

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